Assessment of lung function and diffusion capacity among cases with and without microvascular complications of diabetes mellitus - A cross sectional study

 

 

Abstract              Background: Diabetes mellitus is a major public health problem in India. Microvascular complications add burden of the disease in terms of increasing mortality and morbidity. The well known fact is that microvascular complications usually affect eyes, nerves and kidneys and hence the aim of this study is to find out the lung function and diffusion capacity among cases with and without microvascular complications of type 2 Diabetes Mellitus. Methods: A cross-sectional study was conducted among type 2 diabetes mellitus cases presented to outpatient department of general medicine in Thiruvarur Medical College, Thiruvarur, from September 2017 to December 2017. A total of forty patients with type 2 diabetes mellitus were included after assessing the inclusion and exclusion criteria. Data was collected by the principal investigator using a proforma. Data entry was done using Microsoft excel and the statistical analysis like independent sample t test, analysis of variance (ANOVA) and odds ratio were calculated using Statistical Package for Social Sciences (SPSS) software version 17. Results: This study found significant difference between duration of diabetes, fasting and post prandial blood sugar, HbA1c, serum cholesterol and triglycerides with the presence and absence of microvascular complications. FEV1 was found to be reduced among patients with microvascular complications (p=0.0049). Also with reduction in DLco, diabetic nephropathy and retinopathy were found to be statistically significant among cases with microvascular complications. Conclusion: FEV1 and DLco can be recommended for routine screening in all type 2 diabetic individuals for early identification and for assessing the progression of lung dysfunction.

Key Word: Diabetes mellitus, lung function, microvascular complication, diffusion capacity