Incidence of non-alcoholic liver diseases in hypothyroidism

 

 

Abstract              Prevalence of hypothyroidisms is an alarming condition in India. It has been also observed that hypothyroidism is also associated with various other co morbidities of metabolic syndrome due to the crucial role of thyroid hormone in metabolism. Hypothyroidism has been identified as an important risk factor for both hepatic and cardiometabolic mortality. Endocrine hormones play an important role in various key metabolic processes and their dysfunction leads to metabolic abnormalities. Thyroid hormone plays an important role in energy homeostasis, lipid and carbohydrate metabolism, regulation of body weight and adipogenesis. Its dysfunction may alter various metabolic processes. Abnormal lipid metabolism may lead storage of fat in liver which is known as non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH). Hypothyroidism is prevalent among patients with NAFLD/NASH. The present study observed significant increase in circulatory levels of ALT and AST in hypothyroidism patients than control.

Key Word: Thyroid dysfunction, Hypothyroidism, Non alcoholic steatohepatitis, Non alcoholic fatty liver disease