Circulatory levels of HsCRP in non-alcoholic fatty liver disease

 

 

Abstract              Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalence cause of cardio mortality due to subclinical inflammation. Various factors play an important role in setting the subclinical inflammation. Job profile extended working hours, sedentary life style, and unhealthy dietary habits as well modulation of genetic factors make NAFLD as one of the leading underlying causes or the result of various diseases. It is mainly characterized by abnormal deposition of fat in liver followed by production of inflammatory mediators. HsCRP is one of the proinflammatory mediators which indicate the level of inflammation. HsCRP is also identified as one of the cardiac marker.  The pathophysiology of NAFLD is not fully understood, although it is often related to insulin resistance, Diabetes and Cardiovascular complications. Aim: The aim of this study was to evaluate the circulatory levels of HsCRP in patients of non-alcoholic fatty liver disease and compare them with clinically healthy controls. Results: The present study observed a significant increase anthropometric parameters and lipid parameters in patients than controls. TG and LDL have shown an increased pattern in circulatory levels in serum. Abnormal lipid profile reported high TG and LDL in patients than controls, TG [158.22 (±80.11)/ 110.68 (±43.21)] and LDL [120.16 (±45.32)/ 99.30 (±32.80)]. A significant difference was found in circulatory levels of ALT in hypothyroidism patients than controls [46.3(± 3.8) /19.24(± 3.1)]. Conclusion: The present study concluded that HsCRP can be considered as an important marker of inflammatory status in NAFLD and NASH.

Key Word: Inflammatory Markers, NAFLD, NASH, HsCRP