Metabolic syndrome in HIV/AIDS in Manipur

 

Hidangmayum Dwijaraj Singh¹, Thiyam Brojendro Singh^2*, Rothangpui³, Konsam Biona Devi⁴, Abhik Dev⁵, Banteilang Challam⁶

 

¹Assistant Professor, ²Associate Professor, ⁴Senior Resident, ^5,6Post Graduate, Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal.

 

Abstract              Background: Metabolic syndrome is a complex disorder considered as a worldwide epidemic. A variety of endocrine and metabolic disorders are seen in the context of HIV infection which may be direct consequence of HIV infection, secondary to opportunistic infections or neoplasm, or related to medication side effects. Aims and Objective: To determine the prevalence of metabolic syndrome among HIV infected and the risk factors for the development of cardiovascular disease and other associated risk in patients on HAART. Material and methods: This is a cross sectional carried out in the Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal to determine the prevalence of metabolic syndrome among HIV infected population and the risk factors for the development of cardiovascular disease and other associated risk in patients of HAART. Results and conclusions: Metabolic syndrome was present in 8 cases (5.4%) of which 2^nd line HAART had 7 cases, 1case in alternative 1^st line HAART and no case in 1^st line HAART group. These difference is statistically significant (p<0.05). Hypertension was present in 6% of patients with ART. Males had more abnormal waist circumference than females and those on 2^nd line HAART treatment group had more abnormal waist circumference. Fasting blood sugar was present in 10% cases. Increased triglyceride level was more among the 2^nd line HAART group. Serum HDL level was low in 18 % of cases. Patients on HAART had mean risk of 2.2% with a standard deviation of 3.9 % and on comparing among HAART groups mean risk score was 3.0% among 2^nd line, 2.9% among alternative and 1.2% among 1^st line. This finding was statistically significant (p<0.05).

Key Word: Metabolic syndrome, Manipur.