Correlation of homocysteine and lipid profile parameters with ischemic heart disease

 

 

Abstract              Background: An inverse association between homocystine and lipoproteins, especially high-density lipoprotein cholesterol, has been well described in humans. Elevated homocysteine levels in serum or plasma is a strong and independent risk factor for occlusive arterial disease, and of venous thrombosis. Aim: To investigate the association of homocystine level and lipid profiles with ischemic heart disease. Material and Methods: Hundred Ischemic Heart Disease patients were included as cases and 150 normal healthy populations was selected as controls. Quantitative determination of total L-homocysteine in human serum or plasma was done by using Chemiluminescent Microparticle Immunoassay (CIMA) technology and Cholesterol, HDL, Triglycerides were measured enzymatically using specific reagents. Results: The number of individuals with high homocysteine levels was 75 out of 100 in patient group and 79 out of 150 in control group (p-value <0.05). No significant difference between lipid parameter levels among the cases and controls found. Conclusion: The homocysteine levels were not significantly affected by the presence or absence of deranged lipid profile. Thus, we found that homocysteine is an independent risk factor for IHD.

Key Words: Ischemic heart disease, homocysteine, cholesterol, triglyceride