A study of co-relation of vitamin D level and risk factors in a patient of diabetes mellitus

 

 

Abstract              Background: Vitamin D insufficiency has long been suspected as a risk factor for type 1 Diabetes based on animal and human observational studies. The study under discussion was undertaken to determine the correlation of Vitamin D level to the other risk factor of Diabetes, glycemic control, and duration of Diabetes and treatment of Diabetes. Materials and Methods: A study of co-relation of Vitamin D level and other risk factors of Diabetes in patients attending the outpatient department and indoor department of civil hospital, Ahmedabad was done using Vitamin D level in year 2017-2019. All the patients and the control subjects underwent a through clinical examination. The following investigations were done HbA1c, S cholesterol, S triglyceride estimation, Fasting blood sugar after an overnight fast, Post prandial blood sugar 2 hours after lunch and Vitamin D level estimation in all subjects. Results: Patient with well controlled Diabetes (HbA1c < 7) had a mean Vitamin D level 28.48(ng/ml) which was on higher side as compared to patient with poorly controlled Diabetes. In control group one subject had deficient Vitamin D, 11 having insufficient and 18 had adequate level of Vitamin D. Hypovitaminosis D is 4.12 times more common in diabetic patient as compared to age and gender matched control. In our study 73% diabetic patient had insufficient Vitamin D level as compared to 40% in control group. In our study mean Vitamin D level in diabetic patients was 24.25(ng/ml) and in control group 32.21(ng/ml). Conclusion: Vitamin D deficiency appears to be detrimental to beta-cell function, and leads to glucose intolerance in animal models and humans, consequently type 2 Diabetes. In our study we found that Vitamin D co-related with other risk factors of Diabetes. Vitamin D deficiency was common in patients with Diabetes Mellitus and deficiency was much more in patients having more than one risk factor for Diabetes. Vitamin D deficiency is associated with poor Glycemic control.

Key Words: Diabetes mellitus, Vitamin D deficiency, HbA1C, BMI, Cholesterol.