A study of prevalence and factors associated with organo phosphorus poisoning at tertiary care center

 

Pandit Kishanrao Deshmukh¹, Manohar Shankarrao Chavan^2*

 

Abstract              Background: Organophosphate (OP) poisoning is a common problem particularly in developing countries, with one million serious unintentional poisonings and an additional two million hospital admissions for suicidal attempts every year. In general, accidental poisoning is more common in children; whereas poisoning with suicidal intensions is more common in young adults. OP compounds inhibit acetylcholinesterase, resulting in the accumulation of acetylcholine and overstimulation of cholinergic synapses. Materials and Methods: The current study was conducted with an objective of assessing the profile of organophosphate poisoning and factors affecting the outcome in a tertiary care hospital. The current study was a prospective observational study, conducted in the emergency department of medical inpatient ward and ICU of ***** medical college and Hospital, between June 2018 to July 2019. Patients >18 years admitted to emergency department organophosphorus or carbamate poisoning were included in the study. Results: One hundred patients presented to the hospital between June 2018 to July 2019 of which 71% were males. About 59% of the patients belonged to 21-30-year group and 67% of them reached our hospital in <6 hours. Grade 1 poisoning was observed in 45% of patients, a dose of <500 units of pseudo cholinesterase was given to 40% of them. A Glasgow Coma Score >10 was found in 75% of the patients and the overall mortality of OP poisoning was 17%. Conclusion: OP poisoning is more common among younger population, below 30 years with male preponderance. Favourable outcome determinants were younger age, female gender, being admitted to the hospital before 6 hours of OP consumption.                                      

Key Words: Hospital, Organophosphates, Poisoning.