Clinico epidemiological features of dengue virus infection and correlation with serum ferritin levels

 

 

Abstract              Problem Statement: Dengue is an acute systemic viral infection transmitted between humans by Aedes mosquitoes. Today the prevalence of Dengue infection to be almost 390 million per year, but only one fourth manifest clinically and are diagnosed. Our Determination of serum Ferritin level in Dengue patients and correlation of same, with severity and complications. Methods: The study was conducted in the Out-patient Department and in patient department of PMCH and newly diagnosed or suspected 200 adults and children were included during the period August 2017 to July 2018 in our study. Results: Therein lies the potential for serum ferritin to contribute. We performed the measurement of serum ferritin in 57 samples on the day of admission. These values are again grouped and searched for statistical significance. There was significant difference between the groups in terms of serum ferritin. The ROC analysis with each group concluded that a value of serum ferritin less than 1056 ng/ml is very likely to be non severe dengue and a value more than 1679ng/ml is probably going to be severe one. In between values, the prognosis couldn’t be actualized but likelihood of non severe dengue with warning signs would be more. Serum ferritin measurement was also significantly low in DENV1 infection. Conclusion: Serum ferritin is a fairly good marker to prognosticate the severity. The values at the time of admission are significantly different in all the three groups of severity. It thus can be used as surrogate for predicting the course of illness.