A case of pyrexia of unknown origin, latent mycobacterial tuberculosis infection with haemophagocytic lymphohistiocytosis - A rare association

 

Ankan Pathak^1*, Nirmalya Roy², Suman Sarkar³

 

Abstract              Background: Haemophagocytic lymphohistiocytosis (HLH), previously named as Macrophage Activation Syndrome is a rare but potentially fatal disease of normal but overactive histiocytes and lymphocytes that commonly appears in infancy although it has been seen in all age groups. Fever, hepatosplenomegaly, pancytopenia, lymphadenopathy, and rash often comprise the initial presentation. Cutaneous involvement occurs in as many as 65% of patients. Here we report a rare case of Pyrexia of Unknown Origin with LTBI associated with HLH.

Keywords: HLH, IGRA, LTBI.