Study on lipid profile and it’s correlation to the severity of cirrhosis of liver

 

 

Abstract             Background: Cirrhosis is a pathologically defined entity that is associated with a range of characteristic clinical manifestations with fibrosis and the conversion of normal liver architecture into structurally abnormal nodule. Early diagnosis and definitive treatment of the etiology plays an important role in the prognosis. Cirrhosis was believed to be irreversible; however, it has become apparent that there can be reversal of fibrosis by removing the etiological agent. With this background our study was aimed to observe lipid profile in patients with liver cirrhosis and to observe the correlation between lipid profile and the severity of cirrhosis of liver. Materials and Methods: A cross-sectional study was conducted on 100 patients who were admitted in a teaching hospital with the liver cirrhosis. Liver cirrhosis was diagnosed based on Clinical findings, Ultrasonography of abdomen (USG) findings and on biochemical parameters. For assessment of severity of liver cirrhosis, Child Pugh criteria was used in which the cirrhotic patients was divided into three classes. Results: Out of total of 100 patients, most of the patients were between 45-55 years of age. Average age of the patients was 54.5+8.5 years. Among the 100 patients 76 were male and 24 were female. Based on the Clinical findings, Ultrasonography of abdomen (USG) findings and biochemical parameters the patients were classified in to three classes of Child Pugh. Patients among the ‘Class C’ of Child Pugh score, the mean total cholesterol value was 98.0 mg/dl, which was lowest when compared to other classes with statistical significance (p <0.001). Patients among “Child Pugh Class A” had a mean cholesterol value of 122.31 mg/dl, whereas in “Child Pugh Class B” the mean triglyceride level was 107.42mg/d1 and in patients with “Child Class C”, the mean triglyceride level was 83.51 mg/dl. The result was statistically significant with the ‘p value’ <0.001. In the sample studied, patients in Child Pugh class C has least mean HDL level of 20.02 mg/dl, and patients in Child Pugh Class B has slightly higher mean HDL level of 26.45 mg/dl. Patients in the “Child Pugh Class A” had highest mean value of 41.25 mg/dl. The results were significant with a p value <0.001. Conclusion: In our study all the parameters in lipid profiles were found to be significantly decreased in patients with liver cirrhosis. It was also observed that all the parameters of lipid profiles were significantly lower in patients belonging to “Child Pugh Class C” when compared to “class B and A”.

Keywords: Biochemical parameters, Child Pugh score, Cirrhosis, Lipid profile, Uiltrasonography.