Association between mean platelet volume with risk factors of myocardial infarction

 

Ranjith K¹, Ganesh Jadhao^2*

 

Abstract              Background: MPV correlates with platelet function and activation and has recently emerged as a potential marker of cardiovascular diseases. MPV has been shown to be increased in patients with acute myocardial infarction (AMI) compared to stable angina patients. Aim: To study the association between mean platelet volume with risk factors of myocardial infarction. Material and Methods: Total consecutive 94 cases of Acute Myocardial Infarction were enrolled and were compared with an equal number of age and gender-matched comparison group. Blood Sample was collected within 6 hours on arrival at ICU into EDTA tubes who were subsequently diagnosed having AMI. For measurement of platelet count (PLC), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT), complete blood count was done on Automatic Analyzer. Results: MPV of >11fl was seen maximum in 7 (41.18%) hypertensive cases in STEMI followed by 1 (7.69%) case in NSTEMI. MPV of >11fl was seen maximum in 4 (33.33%) smoking cases in STEMI followed 1 (12.5%) case in NSTEMI. There were no smoking cases in comparison group with MPV values >11fl. MPV of >11fl was seen maximum in 3(30%) alcoholic cases in STEMI followed by 1(16.67%) case in NSTEMI. MPV of >11fl was seen maximum in 3(33.33%) diabetic cases in STEMI followed 1(16.67%) case in NSTEMI. MPV values between 9-11fl were seen in 5 (55.56%) diabetes mellitus cases with STEMI. Conclusion: There was significant association between high mean platelet values and risk of myocardial infarction. STEMI patients have high MPV as compare to NSTEMI and comparative group. MPV is a very low-cost investigation available easily in most healthcare settings. In smoking and hypertension patients, MPV values can be used an early marker for CAD.

Key Words: Mean platelet volume, myocardial infarction, hypertension, smoking, alcohol, diabetes.