A comparative study of lipid profile in IHD patients and healthy controls

 

Pandit Kishanrao Deshmukh¹, Manohar Shankarrao Chavan^2*

 

¹Assistant Professor, ²Associate Professor, Department of General Medicine, Mahavir Institute of Medical Sciences(MIMS), Shivareddypet(V), Vikarabad, Telangana, INDIA.

 

Abstract              Background: The World Health Organisation (WHO) has drawn attention to the fact that IHD is our modern "epidemic" that affects populations. Hypercholesterolaemia and hypertriglyceridaemia are considered the independent risk factors for Ischemic heart disease. Aim and objective: To compare the lipid profile of Ischaemic Heart Disease patients and matched healthy controls Methodology: Present study was a case control study carried out in patients diagnosed as Ischaemic Heart Disease patients and healthy controls. Data was collected with pretested questionnaire. Data included demographic characters, clinical history (significant past or family history) of the patients and lipid profile. Fasting and postprandial Blood cholesterol, triglyceride, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol were estimated in both cases and controls. Results: Fasting levels of triglycerides (170.65 mg/dl), serum VLDL(34.64 mg/dl) and total cholesterol(187.5 mg/dl) in patients of IHD are significantly higher as compared to those in controls (120.42 mg/dl, 23.78 mg/dl,167.54 mg/dl respectively).The triglyceride level raised significantly from fasting to postprandial with a mean difference of 16.92 mg/dl in controls and it raised significantly from fasting to postprandial with a mean difference of 65.1 mg/Dl (P = 0.0001). VLDL levels increased significantly from fasting to postprandial (mean difference: 12.48 mg/dl, P <0.000) in IHD patients and it increased by 2.61 mg/dl in control. The levels of total cholesterol (mean difference 12.27mg/dl), HDL (4.62mg/dl) and LDL (20.41mg/dl) decreased from fasting to postprandial in IHD patients. Similarly it decreased by 2.61mg/dl, 2.11mg/dl and 4.01mg/dl in controls respectively.

Key Word: lipid profile in IHD.