Studying the lipid profile in type 2 diabetes mellitus patients and it’s correlation with HbA1c

 

Vivek Kuhite^1*, Sheela Lawate², D P Bhurke³

 

Abstract              Background: Glycated hemoglobin (HbA1c) is routinely used marker for long term glycemic control. In accordance with its function as an indicator for the mean blood glucose level, HbA1c predicts the risk for the development of diabetic complication in diabetes patients.[3] Type 2 diabetic patients have markedly increased risk of coronary heart disease than similarly dyslipidemic non diabetic subjects. diabetic (dyslipidemia) is characterized by 3 lipoprotein abnormalities: elevated very-low-density lipoproteins (VLDL), small LDL particles, and low high-density lipoprotein (HDL) cholesterol (the lipid triad).[4] In our study total 100 patients were taken and cross-sectional observational study was done. we have included both male and female of age more than 30 years and Male: female ratio was 1.32:1. Height, weight, Body Mass Index (BMI) was measured and baseline investigations like complete blood count, fasting and post prandial blood sugar, lipid profile, HbA1C and other investigations like serum urea, creatinine, electrolytes, cholesterol, urine analysis and chest x-ray were carried out as per the necessity.  In the study we observed that, mean values were higher for Sr. HDL in patients on treatment and for rest parameters, it was higher for Sr. Cholesterol, Sr. LDL, Sr. VLDL and Triglycerides in patients who were not on treatment currently. This association of Lipid Profile of the study subjects with the status of the treatment was statistically significant for all the parameters of lipid profile except Sr. HDL. This study showed significant correlation between HbA1C and lipid profile parameters between the two groups (≤ 7% and >7% of HbA1C). The results suggested the importance of glycemic control in order to manage dyslipidemia in type 2 diabetes. So, HbA1C, glycemic control as well as lipid profile indicator can be used for screening of high risk patients for early diagnosis of dyslipidemia.

Key words: diabetes, HbA1C, lipid profile.