A study of correlation of thyroid dysfunction on lipid abnormalities in post menopausal women

 

Shigil Mathew Varghese^*, Arun Kumar S^**, Babu R^**, Sakthivel V^***, Nikil Sam Varughese^*

 

Abstract              Objective: 1) To study the effects of thyroid dysfunction on lipid profile. 2) To study the prevalence of thyroid dysfunction in postmenopausal women Methods: Type of study: Prospective Randomized case control study, Sample size: 100 Postmenopausal women who will be attending the outpatient and inpatient of Medicine department in Vinayaka Missions Medical College and Hospital, Karaikal. Inclusion Criteria: Postmenopausal women attending outpatient and inpatient of Medicine Department. Exclusion Criteria: Known cases of diabetes mellitus, Known cases of Thyroid dysfunction, Known cases of hypertension, Known cases of Chronic kidney disease, Patients on Hormone replacement therapy, Diagnosed cases of Ovarian and uterine malignancy, Patients on drugs like iodide, amiodarone, salicylates, propranolol, octreotide, phenytoin, lithium, glucocorticoid, amphetamine, aminoglutethemide, somatostatins. statistically analysed. Conclusion: It was observed that postmenopausal women with thyroid dysfunction, especially subclinical hypothyroidism, had lipid abnormalities. Lipid abnormalities seen in subclinical hypothyroidism patients are mainly in the form of significant elevation of total cholesterol and HDL. According to this study, thyroid dysfunction is directly related to total cholesterol and HDL changes (p< 0.01).Changes have also been noted with thyroid dysfunction and Non HDL Cholesterol mainly LDL and VLDL but, they were not statistically significant. Therefore, in post menopausal women with thyroid dysfunction evaluation of lipid profile should be made mandatory to avoid the risk of Coronary artery disease, Cerebrovascular accident.

Key Words: thyroid dysfunction, lipid abnormalities.