Role of Vitamin - D in cases of COPD

 

 

Abstract              Problem statement: Chronic obstructive pulmonary disease (COPD) is one of the most common lung diseases. There are two main forms of COPD: Chronic bronchitis is identified by a long-term cough with mucus and Emphysema is a slow destruction of the lungs over time. Most people with COPD have a combination of both conditions. Symptoms include cough with mucus, shortness of breath that worsens with mild activity, fatigue, frequent respiratory infections, and wheezing. Symptoms vary and become worse at times. Methods: Patient were attending Chest and TB OPD of the MGM Medical College and L S K Hospital Kishanganj Bihar diagnosed to be suffering from COPD by X-Ray, PFT and clinical findings will be selected for the study. Total no of cases ~50 were taken for study. Healthy individuals not suffering from any infection or serious disease were selected as control group. Results: Study was to access the Vitamin-D status in COPD subjects because recent evidence suggests Vitamin-D has potent exo-skeletal effects. Such as suppression of inflammation and strengthening of mucosal immunity by synthesis of anti-microbial peptides. We designed our study to carry out a case control study in COPD subjects after clinical and radiological diagnosis from the Chest and TB Department. Routine biochemical parameters were also investigated. Routine blood glucose level among the test and control group were not statistically significant p Value (0.506). Blood urea and serum creatinine level as observed in our study were not statistically significant, p Value <0.01 for both the parameters. We observed a significantly low value of 25-Hydroxy Vitamin-D in subjects of COPD and the level was in deficient range for control group. We found optimum level of 25-Hydroxy Vitamin-D with significant p Value <0.001. Conclusion: Available data from observational studies indicate that reduced level of 25Hydroxy vitamin-D is associated with increased risk of respiratory tract infection. Some results were from different randomised control trials on the protective role of vitamin-D against respiratory tract infection are inconclusive, so more studies are required.

Key Words: COPD, 25Hydroxy vitamin-D.