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Table of Content - Volume 20 Issue 2 - November 2021


 

Efficacy of triple combination mesotherapy with (triamcinolone acetonide, adipose derived stem cells extract and growth factors and aminoacids, vitamins and biomimetic peptide complex) in patients of alopecia areata

 

Sreevidya V1, M Madhavi Latha2*, T Praveena3

 

1Post Graduate, 2Professor, 3Associate Professor, Department Of DVL, Santhiram Medical College & General Hospital, NH-40, Nandyal, Andhra Pradesh, INDIA.

Email: vidya7850@gmail.com, vc.madhavi@gmail.com, praveenathiriveedhi@gmail.com  

 

Abstract              Background: Alopecia areata is an autoimmune, chronic inflammatory disease that causes non-scarring hair loss of scalp and body hairs. It affects 1% of the general population. Genetic, environmental, and autoimmune factors are considered to play most possibly a role in its etiology. Alopecia areata is a T cell-mediated organ-specific autoimmune disease. Aims And Objectives: To determine the efficacy of Mesotherapy with Triamcinolone acetonide, Adipose-derived stem cells extract and growth factors and amino acids, vitamins, and biomimetic peptide complex. Methods: An observational prospective study was conducted from November 2020 to April 2021 with a total of 30 patients with alopecia areata on the scalp to the department of DVL, OPD; Santhiram medical college and general hospital, Nandyal. A detailed history was taken in a prestructured proforma. A thorough clinical cutaneous and scalp examination was done. Results: The earliest age of onset recorded was eight years. The vertex region of the scalp was most commonly involved, followed by the frontal area. Dermatoscopy findings were empty follicles 53.3%, white dots 43.3%, exclamatory mark 6.6%, hidden hair 46.6%, black dots 33.3%, broken hair 16.6% , kinky hair 6.6% , bent hai13.3%. Association with other diseases were seen as atopy 5 (16.6%) thyroid disorders 16(53.3%). Access to SALT score 17 (56.6%) showed significant improvement, 10 (33.3%) showed moderate improvement, 3 (10%) showed poor improvement. Conclusion: scalp was the most common site affected with the vertex area being the most common region. Alopecia areata was commonly Associated with atopy, Thyroid disorders. Mesoneedling with Triamcinolone acetonide, Adipose-derived stem cells extract and growth factors and amino acids, vitamins, and biomimetic peptide complex has a significant benefit in converting vellus hairs to terminal hair. It has the potential to become a therapeutic modality of treatment in recalcitrant alopecia areata.

Key words: Alopecia areata (AA), Mesoneedling, Triamcinolone acetonide (TA), black dots (BD).