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Table of Content - Volume 21 Issue 2 - February 2022


 

Study of role of N terminal pro brain natriuretic peptide in congestive heart failure at a tertiary hospital

 

Rishi Kumar V1*, Senthil Kumar Shakthivel2

 

1Assistant Professor, 2Associate Professor, Department of General Medicine, Shri Sathya Sai Medical College and Research Institute, INDIA.

Email: rishimddoc@rocketmail.com

 

Abstract              Background: Heart failure is the end spectrum of most of the cardiovascular diseases and leading cause of death due to cardiac diseases. Recombinant pro brain natriuretic peptide also known as nessiritide has been used in the treatment of congestive heart failure. This study is based on the role of Natriuretic peptides and their implication and role in congestive heart failure. Material and Methods: Present study was cross sectional, case-control study, conducted in patients with clinical features of heart failure and reduced left ventricular ejection fraction (ejection fraction less than 40%) by 2D echocardiography finding were selected as cases. 40 patients in the similar age group with no clinical features and imaging evidence of congestive heart failure were selected as controls for the study. Results: The mean value of NT PRO BNP among the cases was 2589 pg/ml, and the mean value of NT PROBNP in the control group was 70 pg/ml, indicating a strong correlation of the levels of serum NTPROBNP with congestive heart failure. The mean left ventricular ejection fraction was 34.75% among the cases and 62.5% among the control group. Systemic hypertension was the major risk factor among the cases, 47.5 % of the patients had systemic hypertension, 35% patients had type-2 diabetes, 32.5 % of patients had ischemic heart disease. Maximum number of patients belonged to class III NYHA heart failure, followed by class II NYHA. The mean value of NTPROBNP was the highest among patients with class IV NYHA heart failure, followed by class III NYHA and class II NYHA heart failure. There is a strong correlation between clinical grades of heart failure and the levels of NTPROBNP. Conclusion: NT-pro BNP is a good marker of left ventricular dysfunction in the absence of confounding factor like renal dysfunction, elderly age, critical illness and anemia.

Keywords: NT-pro BNP, left ventricular dysfunction, congestive heart failure, NYHA class