Study of Hyperhomocystienemia as a cause/effect in venous thrombosis

 

 

Abstract Background: Hyperhomocysteinemia has been hypothesized to be associated with heightened risk of venous thromboembolism. Hence the study has been conducted to study association of hyperhomocysteinemia as a cause/effect in venous thrombosis. Materials And Methods: It is an observational study conducted in a tertiary care setup of 42 patients over a period of 18 months. Patients with cortical venous thrombosis, pulmonary vein thrombosis, deep vein thrombosis, hepatic vein thrombosis were included in the study and their clinical history, detailed investigations, course in the ward noted and patients who found to have hyperhomocysteinemia were evaluated for its causative role in thromboembolism. Observation And Results: Out of 42 patients (13 females and 29 males) with mean age being 42.22 with standard deviation of 7.24, 19 patients had hyperhomocysteinemia in patients with B12 levels less than 180, 15 had high homocysteine in patients with B12 between 180-210, 2 patients had B12 level between 210-350pg/ml. It is significantly associated with MTHFR gene mutation with p value of less than 0.001 which is statistically significant. Conclusions: Cyanocobalamine deficiency, folic acid deficiency and MTHFR gene mutation has probably got causal relationship with hyperhomocysteinemia and that detection of b12, folic acid level and gene mutation should be done in all patients to optimize therapy.