Co-relation of cerebral venous sinus thrombosis with vitamin B12 and homocysteine levels in a tertiary care centre

 

Sohan B^1*, Hamsa Manasa K²

 

Abstract              Background: Cerebral Venous Sinus Thrombosis still remains the most common cause of treatable and reversible causes of stroke in young. High levels of homocysteine cause oxidative damage to vascular endothelium with the proliferation of vascular smooth muscle and create a prothrombotic environment through its action on platelets, thrombin, and fibrin. Present study was aimed to study co-relation of cerebral venous sinus thrombosis with vitamin b12 and homocysteine levels in a tertiary care center. Material and Methods:Present study was hospital based, prospective and observational study, conducted in patients aged above 18 years, of either gender, diagnosed clinically and radiologically as cerebral venous sinus thrombosis. Results: In present study 62 patients of CVST were considered. Majority were from age group of 31- 40 years (33.87 %) followed by 19-30 years (25.81%). Male patients (66.13 %) were more than females (33.87 %). Smoking (24.19 %) and alcohol consumption (33.87 %) were also noted. In present study, most common sign and symptoms were headache (69.35 %), visual disturbance (46.77 %), nausea/vomiting (37.10 %), hemiparesis (19.35 %), unconscious (12.90 %), seizure (8.06 %) and speech disturbance (4.84 %). In present study, Hyperhomocysteinemia (HHCy) was noted in 36 patients (58.06 %). GCS score, Motor deficit, Cranial nerve involvement, Seizure, Mechanical ventilator, Sinus (types) involvement and Outcome were significantly associated with hyperhomocysteinemia levels. In present study, Vitamin B12 deficiency was noted in 26 patients (41.94 %). GCS score, Motor deficit, Cranial nerve involvement, Seizure, Mechanical ventilator, Sinus (types) involvement and Outcome were not significantly associated with Vitamin B12 deficiency. Conclusion: Hyperhomocysteinemia is significant in CVST patients and serum hyperhomocysteinemia is a risk factor in the etiology of Cerebral Venous Sinus Thrombosis patients.

Keywords: Hyperhomocysteinemia, Cerebral Venous Sinus Thrombosis, Vitamin B12 levels young patients.