Abstract              Background: The reported incidence of hepatotoxicity and its clinical types is considerable in the medical literature, ranging from 2.5% to 39% Methodology: The study is aimed at studying clinical spectrum of ATT induced hepatotoxicity. Patient attending OPD at a tertiary hospital who are started on AKT and following regularly was included, Patient with tuberculosis who received the full course of ATT without developing hepatitis was formed the control group. The SGPT and SGOT over time the patients of Drug induced Hepatitis taking Antitubercular drugs was monitored. Results: At baseline correlation before starting antitubercular drugs. There were 51 patients that is 79.7% showing SGOT and SGPT less than equal to 40, fifteen days after starting antitubercular drugs there were 22 patients that is 62.9% showing SGOT and SGPT less than equal to 40.one month after starting antitubercular drugs. There were 14 patients that is 48.3% showing SGOT and SGPT less than equal to 40.There were 15 patients that is 57.1% showing SGPT between 41 to 120 and SGOT less than equal to 40, two month after starting antitubercular drugs. There were 12 patients that is 63.2% showing SGOT and SGPT less than equal to 40.There were 46 patients that is 95.8% showing SGOT and SGPT between 41 to 120. Three month after starting antitubercular drugs, 12 patients that is 60% showing SGPT between 41 to 120 and SGOT less than equal to 40, 48 patients that is 98% showing SGOT and SGPT between 41 to 120.four month after starting antitubercular drugs There were 40 patients that is 85.1% showing SGOT and SGPT between 41 to 120.Fivemonth after starting antitubercular drugs; There were 37 patients that is 92.5% showing SGOT and SGPT between 41 to 120. Six month after starting antitubercular drugs There were 38 patients that is 88.4% showing SGOT and SGPT between 41 to 120. Conclusion: It can be concluded from our study that as the time increases the SGPT and SGOT was raised concurrently; at the base majority of the patients were having the values in the normal range but over the time majority were having the deranged means the antitubercular damage liver over the time.

Key Words: SGPT, SGOT, Drug induced Hepatitis, Antitubercular drugs.