Abstract              Background: National Tuberculosis Control Programme (RNTCP) of India, based on the DOTS strategy, patients are treated with an intermittent short-course regimen with drugs administered thrice weekly on alternate days. Aims and Objectives: To study treatment outcomes of sputum smear positive pulmonary tuberculosis re-treatment cases at tertiary health care center. Methodology: After approval from institutional ethical committee this cross -sectional study was carried out in the department of the pulmonary medicine (TB Chest) at tertiary health care center during the year January 2016 to January 2017 in all re‑treatment TB case. So, during one year period total 97 patients included into study after written explained consent. All the necessary information like age, sex etc. was noted. The statistical analysis done of Z-test (Standard error of difference between two proportions ) Result : In our study we have found that the majority of the patients were in the age group of 50-60 were 29.90%, followed by 40-50, 24.74%, >60 were 18.56%,30-40 were 17.53%, and 20-30 -9.28%. The majority of the patients were Male i.e. 58.76% followed by Female -41.24%.Treatment Success were 69.07 %, Treatment not successful were 30.93%. Relapse - 46.39%, Treatment after loss to follow up- 32.98%, Treatment after failure-20.61.Factors associated Treatment not successful were Low SES (Z=2.3792. P< 0.02), Old age (Z= 2.92, P<0.05), Alcohol intake (Z= 2.56, P<0.05), Tobacco use (Z=3.2, P<0.01), Diabetes (Z=4.1, P<0.001). Immunocompromised (Z=5.12, P<0.0001). Conclusion: It can be concluded from our study that Factors associated Treatment not successful were Low SES, Old age, Alcohol intake, Tobacco use, Diabetes, Immunocompromised status etc.

Key Words: Sputum smear positive pulmonary tuberculosis re-treatment cases, National Tuberculosis Control Programme (RNTCP), Directly Observed Treatment Short course (DOTS).