Abstract              Background: The concept of mixed connective tissue disease (MCTD) as a separate immune-mediated connective tissue disease (CTD) was first introduced by Gordon C. Sharp and coworkers > 40 years ago, but there is still no consensus regarding the disease definitions, the classification criteria, or the relationship with other CTDs. Aims and Objectives: To study the profile of mixed connective tissue disorders observed in the department of Medicine of a tertiary health care centre Materials and Method: In the present study all the patients with suggestive mixed connective tissue disease were selected and were tested for serum antibody in high titer (mean =1:149,200) to ribonucleoprotein. Total 28 patients were selected for the study. The demographic details including age, sex was recorded on a prestructured proforma. Presenting Features of the patients with mixed connective tissue disease was also recorded. Laboratory Findings of various laboratory test performed were also recorded. The collected data was entered in the Microsoft excel and was analyzed and presented with appropriate graphs and tables. Results: Male: female ratio was 1: 3.67. Majority of the patients were in the age group of 21-50 years of age. Majority of the patients presented with Arthritis/arthralgia (53.57%) followed by Raynaud phenomenon (17.86%) and Cutaneous lupus erythematosus (10.71%). All patients Antinuclear antibody tests was positive. The Epidermal nuclear IgG deposition was positive in 85.71% patients. Erythrocyte sedimentation rate (>30 mm per hour) was increased in 71.43%. Esophageal dysmotility occurred in 60.71% of the patients. Abnormal pulmonary function tests were present in 57.14% percent of those tested. Conclusion: Thus we conclude that mixed connective tissue disease was common in young female presenting most commonly Arthritis/arthralgia, Raynaud phenomenon and Cutaneous lupus erythematosus. On laboratory test antinuclear antibody tests, epidermal nuclear IgG deposition and raised erythrocyte sedimentation rate were common findings.

Key Words: Mixed connective tissue disease, serum antibody, Arthritis/arthralgia, Raynaud phenomenon.