Abstract              Background: Nephrotic syndrome is a disorder characterized by proteinuria >3.5g/24hr, hypoalbuminemia <3g/dL and peripheral edema. The underlying etiology of the condition is influenced in large part by the age of the patient. In adults aged 15–65 the cause of nephrotic syndrome varies from primary kidney pathologies such as focal segmental glomerulosclerosis, membranous nephropathy, or less commonly minimal change disease. Aims and objectives: To study the clinical profile of patients with nephrotic syndrome ijnn adult at department of medicine of a tertiary health care centre. Materials and method: In the present was retrospective record based descriptive study all the patients of adult nephritic syndrome admitted during January 2015 to December 2016 were enrolled. The detailed history of all the selected patients was recorded on a prestructured proforma including demographic. Clinical examination and biochemical investigations findings wewre also recorded. Renal biopsy findings to know the lesion responsible for the proteinuria were also recorded. Results: Majority of the patients in the present study were young male with age less than 30 years (50%). Followed by 31-40 years of age (21.05%). The proportion of male patients (68.42%) suffering from nephritic syndrome was more as compared to female patients (31.58%). Edema was the most common presenting symptom (81.58%) followed by hematuria (31.58%) and hypertension (28.95%). Anemia was observed in 60.53% patients. Hypoalbuminemia was seen in 86.84% patients. Hypercholesterolemia (>200mg/Dl) was seen in 55.26%. Increased Levels of Creatinine and RBSc in urine were observed in 34.21% and 36.84% patients. The most common lesion responsible for the nephrotic syndrome in adults was Focal Segmental Glomerulosclerosis (44.74%) followed by Membranous Glomerulonephritis (15.79%) and Membranoproliferative glomerulonephritis (13.16%) were observed. Conclusion: Thus we conclude that the most common lesion responsible for the nephrotic syndrome in adults was Focal Segmental Glomerulosclerosis (FSGS) 2^nd common lesion was Membranous Glomerulonephritis (MGN) and 3^rd common lesion was Membranoproliferative glomerulonephritis. Adult nephrotic syndrome was seen commonly in young male. Commonest mode of presentation was edema followed by hematuria and hypertension. Hypoalbuminemia and anaemia were common laboratory findings.

Key Words: Adult Nephrotic Syndrome, edema, Focal Segmental Glomerulosclerosis.