Abstract              Background: Pandemic influenza A (H1N1) 2009 is a novel strain of influenza A virus evolved by genetic reassortment. The Influenza A H1N1 in humans can be a mild illness or in some people it may result in serious, even life-threatening complications such as pneumonia, acute bronchitis, worsening of chronic conditions, respiratory failure and death. Aims and objectives: To study the outcome and various factors associated with Outcomes in the swine flu patients reporting to the Tertiary health care centre. Materials and Methods: In the present retrospective descriptive, record-based study all the cases of suspected Influenza-like illness attending the study institute during the study period were selected and were investigated further. The diagnosis of h1n1 influenza A (swine flu) was confirmed by RT-PCR or culture. A predesigned semi-structured Performa was used to collect details such as socio-demographic details, detailed address, clinical data of patient (sign and symptoms, co- morbid condition), diagnostic findings of influenza testing, treatment history (use of ventilator), drug details (oseltamivir received or not), outcome details and details of current pregnancy if pregnant. The collected data was entered in Microsoft excel and was analysed and presented with appropriate tables and digraphs. Results: 87.04% patients were discharged after treatment whereas 12.96% was the mortality due to swine flu. Diabetes mellitus (16.67%) was the most common co-existing medical condition, followed by chronic renal failure (3.70%) and pregnancy (3.70%). Bilateral pneumonia was diagnosed on x-ray in 46.30% patients whereas unilateral consolidation was diagnosed in 11.11% patients. 14.81% patients required ventilator support. There was no statistically significant between age and outcome of h1n1 influenza A (swine flu). The proportion of female (55.56%) was more. Majority of the patients were form urban area and mortality was also higher in urban area. Among the patients with pneumonia 71.43% patients died as compared to the survived patients (59.57%) but the difference was not statistically significant. Out of the total 8 cases which required ventilatory support 7 died and the difference observed among survived and died was statistically significant. Conclusion: Thus we conclude that the case fatality rate of swine flu was 12.96%. Patients with pneumonia, diabetes mellitus, urban residence and requirement of ventilatory support were the associated factors with bad outcome.

Key Words: Swine flu, outcome, factors associated.