Safety and efficacy of intralesional MMR vaccine along with oral zinc in cutaneous warts

 

Sachin Agarwal¹, Prashant Kumar Yadav^2*, Amarjeet Singh Verma³, Harmeet Kaur⁴

 

¹Asociate Professor, ^2,4PG, Resident, ³Assistant Professor, Saraswathi Institute of Medical Sciences, Hapur,

Email: prash6970@gmail.com, drsachin_agarwal@yahoo.co.in, amarjeetverma.av@gmail.com, khushiangel09@gmail.com

 

Abstract              Background: Warts are one of the most common viral infections of humans in which the most frequently used modalities of treatment involve destruction of the affected area, which does not prevent recurrences and often results in scarring and not possible in multiple wart. Immune system plays an important role in the control of warts has led to the concept of immunotherapy for this condition. Objective: To evaluate efficacy and safety by combining two immunomodulator i.e. oral zinc and intralesional MMR vaccine for the treatment of cutaneous warts. Material and Methods: This double blind randomized controlled clinical trial was conducted in department of dermatology at saraswathi institute of medical college, Hapur on 50 patients with warts who were allocated to two groups including MMR group with oral zinc and normal saline group. MMR vaccine was injected intralesionally along with oral zinc in the first group, whereas normal saline was injected into the lesions in the second group. These injections were repeated every 2 weeks intervals for maximum 3 injections. All patients were followed up every 15day interval up to 45 days and then up to 6 months regarding relapses and finally, side effects, probable relapse, and therapeutic outcomes were evaluated and compared. Result: At the end of follow up period, therapeutic outcomes in the first group included complete cure in 80% cases, relative cure in 8% cases, and no cure in 12% cases. In normal saline group, these rates included complete cure in 4% cases, relative cure in 16% cases, and incomplete cure in 68% cases. No significant complication occurred in the two groups. Conclusion: On combining two immunomodulator for treatment of cutaneous wart is slightly better than used individually and is equally safe.

Key Words: MMR vaccine, Wart, Zinc.