Abstract              Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease manifesting itself in various extra-articular signs and progressive articular damage Aims and Objectives: To study Clinical profile of patients with Rheumatoid arthritis. Methodology: This was a cross-sectional study carried out in the patients with clinical features of rheumatoid arthritis at tertiary health care center during the one-year period i.e. January 2016 to January 2017. All the suspected patients with the clinical features of Rheumatoid arthritis were included into the study, all such patients were undergone clinical evaluation and RA test serologically and included into the study so during one-year period there were 57 patients of Rheumatoid arthritis were identified and included into the study. Result: The majority of the patients were in the age group of 30-40 were 49.12%, followed by 40-50-17.54 %, 50-60 were 15.79%, >60  were 12.28%, 20-30  were 5.26%. The majority of the patients were Female i.e. 73% and Male were 37%, the female to male ratio was 2: 1. The majority of the patients were having clinical features of Joint pain - 90%, Malaise -87%, Fever-86%, Joint swelling -85%, Limitation of movements -80%, Joint stiffness -75%, Generalized lymphadenopathy -60%, The most common radiological features were Soft tissue swelling- 80% followed , Joint space narrowing-78%, Juxta articular osteopenia -75%, Joint erosions -42%, Intra-articular loose bodies -23%, Joint subluxation -11% .The most common extra articular manifestation were Episcleritis-9%, followed by Rheumatoid nodules-7%, Mitral regurgitation -5%, Pleuritis -4%, Coronary artery disease , 4%, Sjogrens syndrome in 2% Conclusion: It can be concluded from our study that the majority of the patients were Female , the most common clinical feature were  Joint pain , Malaise, Fever. The most common radiological features were Soft tissue swelling, Joint space narrowing, Episcleritisfollowed by Rheumatoid nodules.

Key Word: Rheumatoid arthritis (RA), Sjogren’s syndrome, RA-Factor.