Abstract              Background: Epilepsy describes a condition in which a person has recurrent seizures due to chronic underlying process. Around 5-10 % population will have atleast one seizure with the higher incidence in childhood and late adulthood. Aim and Objective: To study clinical profile of patients with refractory epilepsy. Methodology: Study was conducted in a tertiary care hospital on 40 patients admitted with refractory epilepsy. Detailed clinical examination and investigations were carried out. Data analysis was done with appropriate statistical tests. Result and Discussion: Maximum no. of patient were in age group of 21-30 years^. Out of total 40 patients 57.5% were males and 42.5% were female patients. Head injury was most common accounting for 25% of total cases. Pallor was most common abnormality seen (30%). Majority of patient of refractory seizures had FS with dyscognitive features (50%) and GTCs was the second most common seizure accounting for 40% of total cases studied.13 patients( that is 32.5%) had altered sensorium.

Key Words: refractory epilepsy.