Abstract              Background: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with CKD, thus, although some patients with CKD will ultimately develop end stage renal disease (ESRD), most patients with CKD will die of CVD before dialysis becomes necessary. Aims and Objectives: To Study Lipid profile disorders in patients with chronic kidney disease undergoing hemo-dialysis. Methodology: After approval from institutional ethical committee a cross-sectional study was carried out in the department of Medicine of a tertiary health care centre during one year period i.e. November 2016 to November 2017. During the one year period 45 (Group A) patients were confirmed and were taking treatment for CRF in the form of regularly hemo-dialysis. Similarly 45 normal patients with matching age and sex were admitted for different condition were also under the same investigations and included into the study (Group B). The statistical analysis done by Chi-square test, unpaired t-test calculated by SPSS 19 version software. Result : In our study we have seen that The average age of the patients were 45.67 ± 7.75 and 46.54 ± 8.65 was comparable to each other (p>0.05, t=3.21,df=88), Male and Female were also comparable (p>0.05, X²=0.44,df=1). In lipid profile The significantly deranged lipids were TC (p<0.001, t = 52.0216, df = 88 ), TGs (p<0.01,t=47.82,df=88), VLDL (P<0.05,t=55.34,df=88) while HDL(p>0.05,t=2.34,df=88), LDL(p>0.05,t=3.42,df=88) were not significantly deranged in the patients of CRF on Hemo-dialysis. Conclusion: It can be concluded from our study that the patients with CRF on Hemo-dialysis are having significantly higher levels of especially TC, TGs, VLDL.

Key Words: Lipid profile, CRF (Chronic Kidney Disease/ Failure).