A comparative study of glycemic control of continuous insulin infusion versus single dose sub cutaneous insulin glargine injection in the patients admitted to ICU

 

B Phaninder Reddy¹, D Bhargava^2*

 

¹Assistant Professor, Department of Medicine, RVM Medical College, Village Laxmakkapaly, Mdl Mulugu, Dist Siddipet, Telangana, INDIA.

²Assistant Professor, Department of Medicine, Viswabharathi Medical College and Hospital, Penchikalapadu, Kurnool, INDIA.

Email: bhargava.dinni@gmail.com

 

Abstract              Background: Diabetes is increasing at an alarming rate affecting more than 371 million people worldwide. Recent estimates report a 5 million increase in prevalence from 2011 to 2012, with many more undiagnosed. Aims and Objectives: To study glycemic control of continuous insulin infusion versus single dose sub cutaneous insulin glargine injection in the patients admitted to ICU. Methodology: After approval from institutional ethical committee a cross-sectional study was carried out in the patients with diabetes admitted to ICU in the department of Medicine of a tertiary health care centre during the one year period i.e. January 2016 to January 2017. After the written explained consent the patients were randomly allotted to the different treatment group i.e. Group A (continuous insulin infusion ) and Group B (single dose sub-cutaneous insulin glargine injection).The statistical analysis was done by Chi-square test, unpaired t-test calculated by SPSS 19 version software. Result: In our study we have seen The patients in the Group A and Group B were comparable with each other with respect to Age (X²=0.8461, df=4, p>0.05). The patients in the Group A and Group B were comparable with each other with respect to Sex (X²=0.3472, df=1,p>0.05) The Mean time averaged AUC of blood glucose level (mg/dl) ±SD for Group A was 152 ± 13.43 and for Group B 154 ± 12.54 was comparable with each other (p>0.05). The outcome in the patients like improvement was comparable in both the group (X²=0.72, df=1, p>0.05), The average hospital stay was also comparable in both the groups (p>0.05) and also with respect to APACHE II Score (p>0.05). Conclusion: It can be concluded from our study that glycemic control of continuous insulin infusion versus single dose sub cutaneous insulin glargine injection in the patients admitted to ICU was comparable to each other so single dose sub cutaneous insulin glargine injection should be preferred as it is having the same effect of continuous insulin infusion.

Key Words: Continuous insulin infusion, cutaneous insulin glargine injection, APACHE II Score.