Abstract              Background: India has the third largest epidemic in the world with 2.1 million people living with HIV. Along with T helper cell dysfunction, there is documented evidence of B cell dysfunction. B cell dysfunction is associated with Objectives: This study was done to evaluate correlation between serum globulins and CD4 count, and role of serum globulins as a marker for immunity. Materials and Methods: This study was done in Kamineni academy of medical sciences and research centre, data was collected from 47 patients and analyzed. RESULTS AND DISCUSSION- most common presentation was anemia (29.7%), 25% had tuberculosis,17% had oral candidiasis, pneumonia and gastroenteritis. Serum globulins had negative correlation with CD4. Serum globulin >3.5 gm/dl had 65% sensitivity and 73% specificity, 72% positive predictive value in predicting CD4 count less than 200cells/cumm. CONCLUSION- Future studies to evaluate the potential use of calculated globulins as marker for immunity during follow up in patients being treated with ART are warranted.

Key Words: HIV, Serum globulins, Immunity.