Study of Hepatitis E infection in a tertiary care hospital in Western Maharashtra

 

Makarand Mane^1*, Priyanka Mane², Mohit Khatri³, Hardik Patel⁴

 

{¹Associate Professor, ^3,4Resident, Department of Medicine} {²Assistant Professor, Department of Microbiology}, KIMS, Karad, Maharashtra.

Email: makarand.mane@gmail.com

 

Abstract              Background: Hepatitis E is the most common cause of acute viral hepatitis in the adult population in India. Acute viral hepatitis E (HEV) is generally mild and self-limiting and resolves within six weeks, with no chronic sequelae. Pregnant women are at increased risk with the risk increasing as the pregnancy progresses near term. Methods: Prospective study is done in Krishna Hospital at Karad in which 70 patients are taken from January 2017-march 2018 and the data is analysed for clinical and outcome of HEV. Results: Out of 70 patients, 65 presented with jaundice which is 92%, 55 presented with nausea and vomiting which is 78%,50 patients presented with anorexia which is 72%, 44 patients presented with abdominal pain which is 62%.Hepatomegaly was present in 24 patients which is 34%, bleeding problems are presented in 22 patients which is 31%.Sleep disturbances, altered consciousness are present in 16 and 12 patients which is 22% and 17%,, hepatic coagulopathy was present in 28 that is 40%, hepatic failure was present in 12 patients which is 17% and from that 3 patients died. 10 patients are having renal failure which is 14%.Out of 12 pregnant women in this study, intra uterine death occurred in 7 females that is 58%.Out of 38 females in this study, 8 females died ( maternal mortality) which is 21%Overall mortality is 11 patients died which is 15%. Conclusion: We found that majority of cases were cured with supportive treatment while risk of mortality and morbidity was more in pregnant women.

Key Words: Hepatitis E.