A Study of Clinico bio chemical profile of the patients admitted with OP poisoning at tertiary health care centre

 

Manish Pendse

 

Abstract              Background: The pesticide poisoning like Organophosphorus (OP) is attributed for the death of around 200,000 people each year, largely in the Asia-Pacific region. Aims and Objectives: to Study Clinico bio chemical profile of the patients admitted with OP poisoning at tertiary health care centre. Methodology: After approval from institutional ethical committee a cross-sectional study was carried out in the patients with history of ingestion of Organo phosphorus compounds (OP), accidental or suicidal brought to casualty or admitted to the department of Medicine during the one year period i.e. March 2016 to March 2017.The severity of poisoning was determined by Pseudo cholinesterase level Severe (≤700 IU), Moderate (701-14,00 IU), Mild (1401-3500 IU), Latent (>3500 IU) . The statistical analyses done by Chi –square test calculated by SPSS 19 version software. Result: In our study we have seen that The majority of the patients were in the age group of 30-40 i.e. 28.36% , followed by 40-50, 25.37%, 50-60 were 19.40%, >60 were 16.42%, 20-30 were 10.45%. The majority of the patients were Male i.e. 55.22% followed by Female i.e. 44.78%. The most common symptoms were Impaired , blurry vision -90%, Excess saliva-85%, Muscle weakness-75%, Dizziness -72%, Coughing and wheezing-68%, Difficulty in breathing-32%, Muscle twitching and tremor-29%, Irregular heartbeat-21%, Respiratory depression -19%. The majority of the patients with severe type of poisoning were having poor outcome or death i.e. 57.89 % as compared to Recovered were 42.62%, in Moderate- the Death or Poor outcome was 31.82 % and Recovered were 68.18%, in Mild Death or Poor outcome were 10.53 % and Recovered were 89.47%, in Latent it was -Death or Poor outcome 0% and 100% recovered. This difference of mortality with respect to severity of poisoning on Pseudo cholinesterase level was statistically significant (X²=14.62,df=3,p<0.002). Conclusion: It can be concluded from our study that The majority of the patients were in the age group of 30-40, most common symptoms were Impaired, blurry vision , Excess saliva, Muscle weakness, Dizziness , the pseudo-choline esterase level significantly associated with the poor outcome or mortality in the patients .

Key words: OP poisoning, pseudo-choline esterase level, Organo-phosporus compounds.