Clinical profile and mortality indicators of dengue fever

 

Dileep Babasaheb Kadam¹, Nagnath Kerba Redewad^2*, Ajay  S Chandanwale³

 

{¹Professor and HOD, ²Assistant Professor, Department of Medicine} ³Dean, B.J.G.M.C and Sassoon General Hospital, Pune, Maharashtra.

Email: nagnath.redewad09@gmail.com

 

Abstract              Background: Dengue fever is an vector born diseases, caused by arbo-virus. it has four sero-types namely, DEN-1, DEN-2, DEN-3 and DEN-4. Materials and Methods: 318 patients of dengue NS1 and IgM positive are included in the observational study and analyzed over period of April 2014 to December 2014 Results: Most common clinical feature was fever (100%) followed by Bodyache and joint pain (81.76%) and headache (48.74%), Retro-orbitalpain(21.38%). Atypical manifestations were pain in abdomen (50%), vomiting (61.63%), Loose motions (8.49%), Peri GB Collection(13.20) and bleeding manifestation like Malena (13.83%) and Hematuria (11.94%) Epistaxis (5.66%), Gum bleed (4.71%). 72 patients had rash and rash associated itching was present in 30.Transaminitis (60.37%) was documented in the form of increase in SGOT more than SGPT. Serositis were observed in form free fluid in abdomen (38.99), Plural Effusion (7.2). Total leuococyte count was normal in 88.67%, but 8.8% patients had leucopenia and 2.5 % with leukocytosis. Out of 64 patients with cardiac involvement 54 had bradycardia, 7 had carditis and 3 patient had anginal pain with ST-T wave changes with positive cardiac biomarkers. 72 patients had dengue shock syndrome out of which 7 patients died with multiorgan dysfunction. Mortality 9 was more common in patients with platelet count <50000 on day one, in patients with serositis, high hematocrit, low systolic blood pressure, deranged renal function and hepatitis. Conclusion: One should aware of atypical presentations of dengue fever for timely diagnosis and intervation with the Indicators mortality

Key Words: Dengue fever; Transaminitis.