Relationship between left ventricular diastolic dysfunction and severity of chronic obstructive pulmonary disease

 

Sham Kamble^1*, Manpreet Singh²

 

 

Abstract              Background: COPD is complicated by a high rate of cardiac diseases. The co-existence of COPD and heart failure has been previously described. Previous Doppler studies have demonstrated that left ventricular diastolic dysfunction (LVDD) is frequently found in severe patients with COPD. Aim: To assess the relationship between left ventricular diastolic dysfunction and severity of chronic obstructive pulmonary disease. Material and Methods: Pulmonary Function Test (spiromerty) and Conventional 2D echocardiography was performed on 125 patients (25 control + 100 COPD patients). FEV1% predicted criteria was used to classify the patients of COPD in GOLD I to IV (>80=I, 50-80= II; 30-50=III; <30= IV). FEV1/FVC<0.7 differentiates COPD patients from control group. Modified medical research council dyspnea scale (mMRC) and COPD Assessment Test (CAT) clinical and questionnaire based scores were used to assess severity of COPD. Results: LVEF was positively correlated with FEV1 (p<0.001).LV end diastolic and systolic volume were positively correlated to FEV1.However, E was negatively correlated with FEV1 (p< 0.001).On the contrary, e (septal) was positively correlated with FEV1 and E/e septal was negatively correlated with FEV1. Conclusion: The occurrence of Left ventricular dysfunction (systolic and diastolic) is more in COPD patients and the dysfunction correlates well with the severity of COPD.

Key Words: Chronic obstructive pulmonary disease, Left ventricular dysfunction, Echocardiography, GOLD.