Home About Us Contact Us

 

Table of Content - Volume 21 Issue 3 - March 2022


 

Study of Hyperhomocystienemia as a cause/effect in venous thrombosis

 

Simran Thakkar1*, Aditya Burje2, Namita Padwal3, Niteen Karnik4

 

1Junior Resident, 2Senior Resident, 3Associate Professor, 4Professor & HOD, Department of Medicine, Lokmanya Tilak Municipal Medical College and Hospital, Mumbai, INDIA.

Email: thakkar_simran@yahoo.co.in

 

REFERENCES

  1. Agata Sobczyńska-Malefora. Hyperhomocysteinemia - an overview | ScienceDirect Topics [Internet]. [cited 2021 Jan 5]. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/hyperhomocysteinemia
  2. Cattaneo M. Hyperhomocysteinemia and thrombosis. In: Lipids [Internet]. American Oil Chemists Society; 2001 [cited 2021 Jan 8]. Available from: https://pubmed.ncbi.nlm.nih.gov/11837987/
  3. Gibson JB, Carson NA, Neill DW. Pathological findings in homocysteinuria. Journal of Clinical Pathology. 1964;17:427-437.
  4. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111-128.
  5. Boger RH, Bode-Boger SM, Sydow K, Heistad DD, Lentz SR (2000) Plasmaconcentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxidesynthase is elevated in monkeys with HHcy or hypercholesterolemia. ArteriosclerThrombVascBiol 20: 1557–1564.
  6. Bouchey CJ, Beresford SA, Omenn GS, Motulsky AG (1995) A quantitativeassessment of plasma homocysteine as a risk factor for vascular disease.
  7. Brouwer IA, van Dusseldorp M, Thomas CM et al. Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J ClinNutr. 1999;69:99-104
  8. Rasmussen K, Moller J, Lyngbak M, Pedersen AM, Dybkjaer L. Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem. 1996;42:630-636.
  9. Lakshmikumar K, Gomti KD, Shugeta ND, Arbind RS. Effect of age on serum homocysteine level among adult urban population of Manipur. J Med Soc 2013;27:46-8.
  10. Omer Sultan M, Farooque U, Javed R, Khan MI, Karimi S, Abdul Sattar R, Cheema O. Correlation of Homocysteine Level and Age in Patients with Ischemic Stroke. Cureus. 2020 Apr 22;12(4):e7785.
  11. P. O'Callaghan, R. Meleady, T. Fitzgerald, I. Graham, European COMAC group, Smoking and plasma homocysteine, European Heart Journal, Volume 23, Issue 20, 1 October 2002, Pages 1580–1586
  12. Desouza C, Keebler M, McNamara DB, Fonseca V. Drugs affecting homocysteine metabolism: impact on cardiovascular risk. Drugs. 2002;62(4):605-16.
  13. Podda GM, Lussana F, Moroni G, Faioni EM, Lombardi R, Fontana G, Ponticelli C, Maioli C, Cattaneo M. Abnormalities of homocysteine and B vitamins in the nephrotic syndrome. Thromb Res. 2007;120(5):647-52.
  14. Wang JW, Li JP, Song YL, Tan K, Wang Y, Li T, Guo P, Li X, Wang Y, Zhao QH. Clinical characteristics of cerebral venous sinus thrombosis. Neurosciences (Riyadh). 2015 Jul;20(3):292-5.
  15. Goyal G, Charan A, Singh R. Clinical Presentation, Neuroimaging Findings, and Predictors of Brain Parenchymal Lesions in Cerebral Vein and Dural Sinus Thrombosis: A Retrospective Study. Ann Indian Acad Neurol. 2018 Jul-Sep;21(3):203-208.
  16. Patil VC, Choraria K, Desai N, Agrawal S. Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center. J Neurosci Rural Pract. 2014 Jul;5(3):218-24.
  17. Botta R, Donirpathi S, Yadav R, Kulkarni GB, Kumar MV, Nagaraja D. Headache Patterns in Cerebral Venous Sinus Thrombosis. J Neurosci Rural Pract. 2017 Aug;8(Suppl 1):S72-S77. doi: 10.4103/jnrp.jnrp_339_16. PMID: 28936075; PMCID: PMC5602266.
  18. Simone B, De Stefano V, Leoncini E, Zacho J, Martinelli I, Emmerich J, Rossi E, Folsom AR, Almawi WY, Scarabin PY, den Heijer M, Cushman M, Penco S, Vaya A, Angchaisuksiri P, Okumus G, Gemmati D, Cima S, Akar N, Oguzulgen KI, Ducros V, Lichy C, Fernandez-Miranda C, Szczeklik A, Nieto JA, Torres JD, Le Cam-Duchez V, Ivanov P, Cantu-Brito C, Shmeleva VM, Stegnar M, Ogunyemi D, Eid SS, Nicolotti N, De Feo E, Ricciardi W, Boccia S. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol. 2013 Aug;28(8):621-47.
  19. Genser D, Prachar H, Hauer R, Halbmayer WM, Mlczoch J, Elmadfa I. Homocysteine, folate and vitamin b12 in patients with coronary heart disease. Ann Nutr Metab. 2006;50(5):413-9.
  20. Wasay M, Khan M, Rajput HM, Farooq S, Memon MI, AlRukn SA, Malik A, Abd-Allah F, Shoaib RF, Shahid R, Nishat S, Awan S. New Oral Anticoagulants versus Warfarin for Cerebral Venous Thrombosis: A Multi-Center, Observational Study. J Stroke. 2019 May;21(2):220-223.
  21. Ikejiri M, Shindo A, Ii Y, Tomimoto H, Yamada N, Matsumoto T, Abe Y, Nakatani K, Nobori T, Wada H. Frequent association of thrombophilia in cerebral venous sinus thrombosis. Int J Hematol. 2012 Mar;95(3):257-62.
  22. Ma, Y., Peng, D., Liu, C. et al. Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12 are significantly correlated with the categories of coronary artery diseases. BMC Cardiovasc Disord 17, 37 (2017).
  23. Zhang Q, Li S, Li L, Li Q, Ren K, Sun X, Li J. Metformin Treatment and Homocysteine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016 Dec 9;8(12):798.
  24. Fallah S, Nouroozi V, Seifi M, Samadikuchaksaraei A, Aghdashi EM. Influence of oral contraceptive pills on homocysteine and nitric oxide levels: as risk factors for cardiovascular disease. J Clin Lab Anal. 2012 Feb;26(2):120-3.
  25. van Ede AE, Laan RF, Blom HJ, Boers GH, Haagsma CJ, Thomas CM, De Boo TM, van de Putte LB. Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis. Rheumatology (Oxford). 2002 Jun;41(6):658-65.
  26. Pushpakumar S, Kundu S, Sen U. Endothelial dysfunction: the link between homocysteine and hydrogen sulfide. Curr Med Chem. 2014;21(32):3662-72.
  27. Ji C, Kaplowitz N. Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J Gastroenterol. 2004 Jun 15;10(12):1699-708. doi: 10.3748/wjg.v10.i12.1699. PMID: 15188490; PMCID: PMC4572253.
  28. Gerritsen T, Vaughn JG, Weisman HA. The identification of ho-mocysteine in the urine. Biochem Biophys Res Commun. 1962;9:593–596.
  29. Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY, Zhou J, Maeda N, Krisans SK, Malinow MR, et al. Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest. 2001;107:1263–1273.
  30. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149–1155.