Table of Content - Volume 6 Issue 1 - April 2017
Echocardiographic evaluation of cardiovascular hemodynamic in preeclampsia
Shripad Vithalrao Dhanorkar1, Balasaheb Eknathrao Karad2*
1Associate Professor, 2Professor and Head, Department of Medicine, Gouri Devi Institute of medical sciences, Rajbandh, Durgapur, West Bengal, INDIA. Email: karadbalasaheb@gmail.com, svdhanorkar@gmail.com
Abstract Background: Pregnancy is associated with volume overload producing significant vascular and hemodynamic adaptations in cardiovascular physiology. Aims and Objectives: To study Echocardiographic evaluation of cardiovascular hemodynamic in preeclampsia. Methodology: After approval from institutional ethical committee this cross-sectional study was carried out in the patients of Preeclampsia referred for the Cardiovascular hemodynamic at tertiary health care centre. All the patients with the written explained consent were enrolled for the study during the one year duration i.e. January 2016 to January 2017. During the one year 35 random patients with preeclampsia and 35 random patients with normal pregnancy were enrolled into the study. The statistical analysis done by unpaired t-test and calculated by SPSS 19 version software. Result : Systolic parameters were LV ESV (ml) -28.21 ± 1.7 and 32.02 ± 11.23 (p>0.92 ), LV EDV (ml)-105.32 ± 3.32 and 110.12 ± 19.21 (p>0.80), SV (ml)-69.51 ± 5.12 and 72.45 ± 9.21 (p>0.92); CO (ml/min)-42.23 ± 3.41 and 70.23 ± 5.1 (p>0.001 ) LVM Diastolic (g)- 101.71 ± 24.52 and 137.11 ± 17.12 (p>0.01) , Systolic (g)- 81.23 ± 19.34 and 91.52 ± 5.67 (p>0.02), ARD (cm)-2.02 ± 0.115 and 3.12± 0.382 (p>0.01), LVOT (cm)-1.62 ± 0.12 and 1.92 ± 0.12 (p>0.13), TVR (dyne, Sec cm5 ) -1195.12 ± 71.18 and 1387.80 ± 160.23 (p>0.01) respectively in Normotensive and hypertensive. The diastolic parameters like E wave, m/s were 0.512 ± 0.112 and 1.823 ± 0.112 (p>0.01), A Wave, m/s - 0.612 ± 0.112 and 0.881 ± 0.121 (p.0.001), E/A ratio-1.62 ± 0.132 and 1.9234 ± 0.571 (p>0.52), E Dec time, ms -129 ± 9.12 and 195.21 ± 50.12 (p>0.05), IVRT, ms-85.72 ± 6.12 and 98.11 ± 7.82 (p>0.05), E VTI, ms-12.32 ± 1.94 and 98.11 ± 7.82 (p>0.05), A VTI, ms-3.82 ± 0.72 and 7.12 ± 2.11 (p>0.05 ). Conclusion: It can be concluded from our study that significantly there were changes in systolic and diastolic parameters of the heart of preeclampsia patients as compared to normal pregnancy hence only blood pressure monitoring is not sufficient it should be accompanied with 2 D echo for monitoring and intervention Key Words: hemodynamic in preeclampsia, Eclampsia, Echocardiography.
INTRODUCTION Pregnancy is associated with volume overload producing significant vascular and hemodynamic adaptations in cardiovascular physiology.1 They are necessary for successful pregnancy, but they impose further load on the heart. Moreover, heart disease is the leading cause of non-obstetric mortality during pregnancy, and the number of pregnant women at risk for cardiovascular complications is on the rise.2,3 Therefore, understanding of maternal cardiac function allows clinicians to detect and manage cardiac disease during early stages. In earlier days, gas exchange techniques were used to determine cardiac output. With development of cardiac catheterization, studies were performed using right heart hemodynamics. The advent of echocardiography enabled serial noninvasive cardiovascular monitoring throughout pregnancy. Initially, investigators used M-mode but perhaps due to its limitations, results were not uniform.4 Recently, Doppler echocardiography has been used which is reproducible and non-invasive technique suitable for pregnant women.5
MATERIAL AND METHODS After approval from institutional ethical committee this cross-sectional study was carried out in the patients of Preeclampsia referred for the Cardiovascular hemodynamic at tertiary health care centre. All the patients with the written explained consent were enrolled for the study during the one year duration i.e. January 2016 to January 2017. During the one year 35 random patients with preeclampsia and 35 random patients with normal pregnancy were enrolled into the study. All the patients under gone 2-D echocardiographic evaluation thoroughly. The statistical analysis done by unpaired t-test and calculated by SPSS 19 version software.
RESULT
Table 1: Distribution of the patients as per the baseline parameters
The average age was 27.32 ± 4.32 and 26.21 ±5.21 Yrs. and BMI was 23.21± 2.32 and 24.52 ± 3.78 which was comparable with each other (p>0.05).
Table 2: Distribution of the patients as per the systolic parameters
Systolic parameters were LV ESV (ml) -28.21 ± 1.7 and 32.02 ± 11.23 (p>0.92 ), LV EDV (ml)-105.32 ± 3.32 and 110.12 ± 19.21 (p>0.80), SV (ml)-69.51 ± 5.12 and 72.45 ± 9.21 (p>0.92); CO (ml/min)-42.23 ± 3.41 and 70.23 ± 5.1 (p>0.001 ) LVM Diastolic (g)- 101.71 ± 24.52 and 137.11 ± 17.12 (p>0.01) , Systolic (g)- 81.23 ± 19.34 and 91.52 ± 5.67 (p>0.02), ARD (cm)-2.02 ± 0.115 and 3.12± 0.382 (p>0.01), LVOT (cm)-1.62 ± 0.12 and 1.92 ± 0.12 (p>0.13), TVR (dyne, Sec cm5 ) -1195.12 ± 71.18 and 1387.80 ± 160.23 (p>0.01) respectively in Normotensive and hypertensive. Table 3: Distribution of the patients as per the diastolic parameters
The diastolic parameters like E wave, m/s were 0.512 ± 0.112 and 1.823 ± 0.112 (p>0.01), A Wave, m/s - 0.612 ± 0.112 and 0.881 ± 0.121 (p.0.001), E/A ratio-1.62 ± 0.132 and 1.9234 ± 0.571 (p>0.52), E Dec time, ms -129 ± 9.12 and 195.21 ± 50.12 (p>0.05), IVRT, ms-85.72 ± 6.12 and 98.11 ± 7.82 (p>0.05), E VTI, ms-12.32 ± 1.94 and 98.11 ± 7.82 (p>0.05), A VTI, ms-3.82 ± 0.72 and 7.12 ± 2.11 (p>0.05 ).
DISCUSSION Pre-eclampsia is a multisystem disorder that occurs after 20 weeks of pregnancy. The incidence of pre-eclampsia in nulliparous women ranges from 3 to 10%6. Acute preeclampsia is associated with significantly higher prevalence of asymptomatic abnormal global left ventricular (LV) abnormal function/geometry and myocardial injury6. It is also associated with significantly higher risk of subsequent heart failure, ischaemic and hypertensive heart diseases, and related mortality compared with uneventful pregnancy in later life7,8. The hemodynamics of preeclampsia is a subject of controversies. Cross-sectional studies of women with preeclampsia have revealed diverse hemodynamic findings such as elevated cardiac output 9,10, high vascular resistance and reduced cardiac output 11 and reduced myocardial contractility 12 In our study we have found that The average age was 27.32 ± 4.32 and 26.21 ±5.21 Yrs. and BMI was 23.21± 2.32 and 24.52 ± 3.78 which was comparable with each other (p>0.05). Systolic parameters were LV ESV (ml) -28.21 ± 1.7 and 32.02 ± 11.23 (p>0.92 ), LV EDV (ml)-105.32 ± 3.32 and 110.12 ± 19.21 (p>0.80), SV (ml)-69.51 ± 5.12 and 72.45 ± 9.21 (p>0.92); CO (ml/min)-42.23 ± 3.41 and 70.23 ± 5.1 (p>0.001 ) LVM Diastolic (g)- 101.71 ± 24.52 and 137.11 ± 17.12 (p>0.01) , Systolic (g)- 81.23 ± 19.34 and 91.52 ± 5.67 (p>0.02), ARD (cm)-2.02 ± 0.115 and 3.12± 0.382 (p>0.01), LVOT (cm)-1.62 ± 0.12 and 1.92 ± 0.12 (p>0.13), TVR (dyne, Sec cm5 ) -1195.12 ± 71.18 and 1387.80 ± 160.23 (p>0.01) respectively in Normotensive and hypertensive. The diastolic parameters like E wave, m/s were 0.512 ± 0.112 and 1.823 ± 0.112 (p>0.01), A Wave, m/s - 0.612 ± 0.112 and 0.881 ± 0.121 (p.0.001), E/A ratio-1.62 ± 0.132 and 1.9234 ± 0.571 (p>0.52), E Dec time, ms -129 ± 9.12 and 195.21 ± 50.12 (p>0.05), IVRT, ms-85.72 ± 6.12 and 98.11 ± 7.82 (p>0.05), E VTI, ms-12.32 ± 1.94 and 98.11 ± 7.82 (p>0.05), A VTI, ms-3.82 ± 0.72 and 7.12 ± 2.11 (p>0.05 ). These findings are similar to Solanki Rizwana 13 found parameters higher in pre-eclamptic subjects as compared to normotensive controls– mean cardiac output (66.85 ± 4.56 ml/min vs. 56.1 ± 1.77 ml/min); mean LV diastolic mass (131.15 ± 16.85 vs. 104.90 ± 23.17 g); systolic mass (88.5 ± 7.34 vs. 83.33 ± 23.84 g); total vascular resistance (1396.85 ± 150.2 vs. 1204.5 ± 71.182 dyne, s cm5 ). Women with preeclampsia delivered smaller babies (2410 ± 426.16 g) as compared to normotensive controls (2895 ± 276.20 g). Different mechanisms have been proposed to explain these changes. Nitric oxide (NO), the vascular smooth muscle relaxing substance acts through cGMP mediated vasodilatation. Enzyme endothelium derived nitric oxide synthase (eNOS) plays important role in its production. Biologically it is present in two isoforms i.e. ca++ dependent and ca++ independent. Increase in estradiol levels during pregnancy increases activity of ca++ dependent eNOS. 13 Also high levels of estrogen and progesterone metabolites (5-α dihydroprogesteron) during pregnancy increases arterial refractoriness to angiotensin II. Increased secretions of ANP by heart in response to atrial distention contribute to vasodilatation which is also mediated by cGMP.14 In normal pregnancy vascular relaxation in peripheral artery and enhanced arterial compliance in conduit arteries plays crucial role in accomodating increased intravascular volume without increase in blood pressure.15
CONCLUSION It can be concluded from our study that significantly there were changes in systolic and diastolic parameters of the heart of preeclampsia patients as compared to normal pregnancy hence only blood pressure monitoring is not sufficient it should be accompanied with 2 D echo for monitoring and intervention.
REFERENCES
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