^1,2Assistant Professor, Department of Dermatology, Gayatri Vidya Parishad Institute of Health care and Medical Technology, INDIA.

³Assistant Professor, Department of Community Medicine, Pinnamaneni Siddardha Institute of Medical Sciences, INDIA.

Email: drtvramanarao94404@gmail.com

RESULT

Table 1: Distribution of the patients as per the sex

The average age of the patients age was (Yrs.) (Mean±SD) 25± 5.6 and of the Patients without Acne was 27± 4.78 which was comparable (p>0.05,t=1.82, df=68). The majority of the patients with Acne were Females as compared to Patients without Acne the sex ratio was 2.5 : 1 and 0.75 : 1 ; Female : Respectively in Patients with and Without acne this difference was statistically significant ( p<0.01, χ² = 5.833, df=1).

Table 2: Distribution of the patients as per the Hormonal assay

The average Serum level of the hormones like LH (mIU/ml) were 13.45 ± 8.21 and 5.12 ± 2.93 (p<0.005,t=5.65,df=68); FSH (mIU/ml) -6.43 ± 3.43 and 4.32 ± 4.12 (p<0.001,t=6.34,df=68), Prolactin(μIU/ml)-421±178.32 and 367.43 ± 115.23 (p<0.05,t=6.34,df=68), Testosterone (mg/ml) - 0.97 ± 0.52 and 0.38 ± 0.17 (p<0.01,t=6.34,df=68) were significantly higher in the patients with Acne as compared to Patients without Acne

DISCUSSION

Acne vulgaris is a common skin disease, affecting more than 85% of adolescents, women being affected more frequently than men⁸. It is seen in nearly 100% of individuals at some time during their lives⁹. For some, it is temporary and resolves by the mid-20s; however, more severe cases often take longer to resolve, and it can persist into adult years in as many as 50% of individuals^7,9. Although it does not affect overall health, its impact on emotional well-being and function can be critical, especially active acne and its sequel, like permanent scarring, leaves psychological stress that do not always correlate with the clinician's assessment of severity at one point in time^10,11. The psychological fallout in acne patients includes much higher rates of clinical depression, anxiety, anger, suicidal thoughts, and even suicide itself¹². Increasing age of affliction with acne can proportionately affect the quality of life in various ways, including employment, social behavior, and body dissatisfaction¹¹. The more severe the acne, the greater the negative impact on quality of life (QOL)⁹. The impact of acne on a patient's psychological and emotional well-being is comparable with that of chronic systemic disease processes such as diabetes, asthma, arthritis, and epilepsy¹¹. Acne is often a chronic disease and not just a self-limiting disorder of teenagers. The following characteristics have been used to define its chronic state: a prolonged course, a pattern of recurrence or relapse, manifestation as acute outbreaks or slow onset, and a psychological and social impact that affects the individual's quality of life. Factors that have been linked to a chronic course include stress-related production of adrenal androgens, P. acnes colonization, familial background, and specific subtypes of acne (conglobata, keloidal, inversa, androgenic, scalp folliculitis, and chloracne)⁶. In our study we have found The average age of the patients age was (Yrs.) (Mean±SD) 25± 5.6 and of the Patients without Acne was 27± 4.78 which was comparable (p>0.05,t=1.82, df=68). The majority of the patients with Acne were Females as compared to Patients without Acne the sex ratio was 2.5 : 1 and 0.75 : 1 ; Female : Respectively in Patients with and Without acne this difference was statistically significant ( p<0.01, χ² = 5.833, df=1). This could be explained by the fact that the Acne are produced in combination with PCOD in the females and the hormonal balance also more common in females. The average Serum level of the hormones like LH (mIU/ml) were 13.45 ± 8.21 and 5.12 ± 2.93 (p<0.005,t=5.65,df=68); FSH (mIU/ml) -6.43 ± 3.43 and 4.32 ± 4.12 (p<0.001,t=6.34,df=68), Prolactin(μIU/ml)-421±178.32 and 367.43 ± 115.23 (p<0.05,t=6.34,df=68), Testosterone (mg/ml) - 0.97 ± 0.52 and 0.38 ± 0.17 (p<0.01,t=6.34,df=68) were significantly higher in the patients with Acne as compared to Patients without Acne Megha Kataria Arora ¹³ et al found that serum testosterone, progesterone, glucocorticoids, insulin and insulin-like growth factors are increased in patients with acne vulgaris and serum estrogen levels are low in patients. B Balachandrudu et al¹⁴ found that Pathogenesis of acne involves a complex interplay of most of the hormones in the Body, which are affected by various endogenous and exogenous stress factors. Hence, a thorough evaluation of the hormonal profile must be done in resistant acne and acne associated with systemic diseases keeping in view the hormonal pathogenesis of acne.

CONCLUSION

It can be concluded from our study that the problem of Acne was more common in Females as compared to Males and the hormones like LH, FSH, Prolactin, Testosterone were significantly higher in the patients of Acne as compared to without Acne patients.

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