Table of Content - Volume 7 Issue 3 - September 2017
A study of the clinical profile and factors associated with guillianbarre syndrome at a tertiary care teaching hospital
A Madhav1, D Anil Kumar2*
1,2Associate Professor, Department of General Medicine, Gandhi Medical College, Musheerabad, Secunderabad -500003, Telangana State, INDIA. Email: anilddrmd@gmail.com
Abstract Background: Guillian–Barre syndrome (GBS), also known as Landry's paralysis1, is an immune-mediated disorder of nervous system, of acute or subacute onset characterized commonly by generalized progressive weakness of lower limbs and upper limbs, limb paraesthesias and relative or complete areflexia. Aims and Objectives: To Study the clinical profile and Factors associated with Guillianbarre syndrome at a tertiary care teaching hospital. Materials and Methods: This was a cross sectional study carried out in the Department of General Medicine, of a tertiary care teaching hospital during the period July 2017 to June 2018. A total of44 patients were included into the study after written explained consent during this period. All necessary details of the patients like age, sex, symptoms and associated factors, if any were noted. The statistical analysis was done by Excel for windows 10. Results: The majority of patients in the age group of 40-50 years were 34.09%, followed by 30-40 years were 22.73%, 20-30 years were 15.91%, 50-60 years were 11.36% and >60 years were 9.09%. The majority of patients were Male -65.91%, followed by Female -34.09%. The majority of patients with symptoms like Weakness of limbs were 93.18%, Sensory symptoms were present in 86.36% and Ptosis/ophthalmoplegia in 27.27%. Patients with Respiratory difficulty were -15.91%, Facial nerve involvement was present in 11.36% and Bulbar symptoms in 6.82%. The majority of patients associated with H/o URTI were27.27%, H/o GI Infections in20.45%, H/o Meningitis in 15.91%, H/o Dengue fever in 9.09%, H/o PUO in 6.82%, H/o Vaccination in 4.55% and Unknown in 15.91%. Conclusion :It can be concluded from our study that majority of patients were in the age group of 40-50 yrs.The majority of patients were Males.The majority of patients were having symptoms like Weakness of limbs, Sensory symptoms and Ptosis/ophthalmoplegia.The patients were associated with H/o URTI, H/o GI Infections, H/o Meningitis H/o Dengue fever, H/o PUO, H/o Vaccination, etc. Key Words: Guillain–Barre syndrome (GBS), Landry'sparalysis, URTI (Upper Respiratory Tract Infections), GI Infections (Gastro Intestinal Infections), PUO (Pyrexia of Unknown Origin).
INTRODUCTION Guillian–Barre syndrome (GBS), also known as Landry's paralysis1, is an immune-mediated disorder of nervous system, of acute or subacute onset characterized commonly by generalized progressive weakness of lower limbs and upper limbs, limb paraesthesias and relative or complete areflexia2. GBS patients often develop cranial nerve weakness, usually in the form of facial or pharyngeal weakness. The usual pattern follows the flaccid paralysis typically ascending in nature evolving over a few days to a few weeks. Autonomic dysfunctions are common with usual manifestations as loss of vasomotor control with wide fluctuation in blood pressure, postural hypotension and cardiac arrhythmias. Respiratory failure and oropharyngeal weakness may require ventilatory assistance in about one-third of hospitalized patients, making it a disease of vital importance for early management2,3. It is believed that GBS may not be a single disease, but a variety of acute neuropathies with a number of related immune-mediated pathogenic mechanisms most common being endoneural inflammation of spinal nerve roots, distal nerve segments and potential nerve entrapment sites2. The reported incidence for GBS is 1-2/100,000 population and increases linearly with age, and men are about 1.5 times more affected than women4. Prior infection such as upper respiratory tract infection is a well-established predating event in the development of GBS by 10-14 days3. Many antecedent illnesses associated with GBS have been identified including Campylobacter jejuni gastroenteritis, cytomegalovirus, Mycoplasma pneumoniae, Epstein-Barr virus and influenza virus infections2,4. Diagnosis of GBS may be confirmed by cerebrospinal fluid (CSF) analysis (albuminocytological dissociation) and Nerve conduction studies.3,4. The commonly recognized variants of GBS are acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor sensory axonal neuropathy (AMSAN) and Miller-Fisher syndrome. AIDP is the most prevalent form and accounts for 70-90 per cent of cases5,6. GBS can occur in any season although seasonal variability may reflect seasonal peaks of predisposing factors such as infections7,8. So we have studied this with clinical features and associated factors if any.
MATERIALS AND METHODS This was a cross sectional study carried out in the patients in IPD, who presented with the clinical features of Guillianbarre syndrome, at Department of General Medicine, Gandhi Medical College, Secunderabad, Telangana State, during the period July 2017 to June 2018.A total of 44 patients were included into the study after written explained consent. All necessary details of the patients like age, sex, symptoms and associated factors, if any were noted. The statistical analysis was done by Excel for windows 10.
RESULTS AND OBSERVATION Table 1: Distribution of the patients as per the age
The majority of patients in the age group of 40-50 years were 34.09%, followed by 30-40years were22.73%, 20-30 years were 15.91%, 50-60 years were 11.36% and >60yrs were 9.09%.
Table 2: Distribution of the patients as per the sex
The majority of patients were Male -65.91%, followed by Female -34.09%.
Table 3: Distribution of the patients as per the clinical features
(*More than one symptom were associated hence the total may be more) The majority of patients with symptoms like Weakness of limbs were 93.18%, Sensory symptoms in 86.36% and Ptosis/ophthalmoplegia in 27.27% of patients. Patients with Respiratory difficulty were -15.91%, Facial nerve involvement was present in 11.36% and Bulbar symptoms in 6.82% of patients.
Table 4: Distribution of the patients as per the associated factors
The majority of patients associated with H/o URTI were27.27%, H/o GI Infections in 20.45%, H/o Meningitis in 15.91%, H/o Dengue fever in 9.09%, H/o PUO in 6.82%, H/o Vaccination in 4.55and Unknown in 15.91%.
DISCUSSION Guillian Barre Syndrome (GBS) has an incidence of 0.4 to 1.9 per 100,000 populations. GBS can occur at any age. The male to female ratio is 3:2. It is characterized by an acute onset, relatively symmetric, predominantly motor, flaccid, areflexic paralysis which evolves over a period of up to 4 weeks. History of antecedent viral infection, vaccination or surgery may be obtained in 50 to 70% of cases. There can be accompanying cranial nerve involvement: Facial (60%), bulbar (30%) or ocular (10%) palsies and respiratory failure in 10-30% of cases. Papilloedema may occur in one percent of cases9. Most of the previous studies have shown that patients present with an antecedent event even up to 6 weeks before the neurological symptoms. In a study by KaushikSundar13 55% of them had antecedent event before getting admitted to the hospital. This was consistent with studies that had been published earlier.10Among the antecedent events that were reported by the patients, fever was the most common one (19%) followed by loose stools (16%). After motor weakness, the next common presentation was sensory disturbances which were seen in 20 patients. Such sensory disturbances have also been reported in previous studies.11The most common cranial nerve that was involved was the facial nerve which was also consistent with the previous studies.11 Respiratory failure was seen as a presenting complaint in 20% of the patients. This correlated with the incidence of respiratory failure that has been previously documented with GBS (10-30%).12 In our study we have seen that the majority of patients in the age group of 40-50 years were 34.09%, followed by 30-40 years were 22.73%, 20-30 years were 15.91%, 50-60 years were 11.36% and>60yrs were 9.09%. The majority of patients were Male -65.91%, followed by Female -34.09%. The majority of patients with symptoms like Weakness of limbs were 93.18%, Sensory symptoms in 86.36%, and Ptosis/ophthalmoplegia present in 27.27% of patients. Patients with Respiratory difficulty were 15.91%, Facial nerve involvement was present in 11.36% and Bulbar symptoms in 6.82% of patients. The majority of patients associated with H/o URTI were27.27%, H/o GI Infections in 20.45%, H/o Meningitis in 15.91%, H/o Dengue fever in 9.09%, H/o PUO in 6.82%, H/o Vaccination in 4.55and Unknown in 15.91%.
CONCLUSION It can be concluded from our study that the majority of patients were in the age group of 40-50 years. The majority of patients were Male. The majority of patients presented with symptoms like Weakness of limbs, Sensory symptoms and Ptosis/ophthalmoplegia. Other symptoms like Respiratory difficulty, Facial nerve involvement and bulbar symptoms were also present in a few number of patients. The patients were associated with H/o URTI, H/o GI Infections, H/o Meningitis,H/o Dengue fever, H/o PUO, H/o Vaccination, etc.
REFERENCES
Policy for Articles with Open Access
|
|