Abstract              Background: Antituberculous therapy induced hepatitis is an important cause of morbidity and mortality in developing countries where the incidence of pulmonary tuberculosis is high. Aims and Objectives: To study the various factors associated with Drug induced Hepatitis in the patients taking Antitubercular drugs at tertiary health care centre. Methodology: Patient attending OPD at a tertiary hospital who are started on AKT and following regularly will be included. Patient from CAT 1 and from CAT 2 attending OPD who are started on AKT was included (pulmonary and extra pulmonary and CAT1 and CAT 2) During one year June 2009 to May 2010. The qualitative variables was analysed by chi- square test. for the comparison of quantitative data, the students t test was applied. The values of p<0.05 were regarded as significant. Result: The Category of DOTS Treatment, BMI, Sex, Alcohol Intake etc. were not significantly associated with the development of Hepatitis (P>0.05). Conclusion: It can be concluded from our study that Correlation between age, sex and incidence of ATT induced hepatitis is controversial and requires further studies. In our study occurrence was more in young males. Correlation between incidence of ATT induced hepatitis and nutrition is controversial and it is more common in people with low BMI in our study. Chronic alcoholism is not an independent risk factor. However history of prior alcohol induced hepatitis or alcohol induced liver disease has been well established as risk factor for drug induced hepatitis.

Key Words: Drug induced Hepatitis, Antitubercular drugs, Risk factors of Drug induced Hepatitis.