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MedPulse - International Medical Journal, ISSN 2348-2516 E-ISSN: 2348-1897

Volume 1, Issue 2, April 2014 pp 129-130

Research Article

A study to determine the effects of monosodium glutamate on insulin secretion and glucose tolerance in healthy volunteers of south Indian population

Praveen Kumar G. S.^*, Carlos Noel Menezes^#, Meghalatha T. S.^*

^*Professor and Lecturer, Department of Biochemistry, Karpaga Vinayaga Medical College and Research Centre, Madhurantagam, Kancheepuram 603308, Tamilnadu, INDIA.

Academic Editor : Dr. Bhanap P. L.

Aim: The aim of this study was to investigate the effects of monosodium (L)-glutamate on insulin secretion and glucose tolerance during an oral glucose tolerance test in healthy volunteers. Materials and Methods: Monosodium (L) glutamate (10 g) packed in capsules were given orally to 20 healthy volunteers, aged 20–30 years, with an oral (75 g) glucose load. Blood samples were taken at 15, 45, 75, 90 and 120 min after the start of the oral glucose tolerance test (OGTT). Results: The increase in serum insulin concentrations after glucose absorption tended to be higher. In the subjects with higher glutamate bioavailability, after glutamate oral administration, significantly higher insulin response was reached. Oral (L)-glutamate enhances glucose-induced insulin secretion in healthy volunteers in a concentration-dependent manner. Discussions: Oral glutamate is able to amplify glucose-induced insulin secretion in a concentration-dependent manner in humans.