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MedPulse - International Medical Journal, ISSN 2348-2516 E-ISSN: 2348-1897

Volume 1, Issue 8, June 2014 pp 417-421

Research Article

To study the clinico-labrotary correlation of stroke due to intracranial extracranial and combined vascular lesions

Anjali Deshmukh¹, Sanjiv Zangde^2
1Consutant Physician, Suryakant Consultant, Nanded, Maharashtra, INDIA.

¹Consutant Physician, Vighnharta Critical Care and Multispecialty Hospital, Borban, Nanded, Maharashtra, INDIA.

Academic Editor : Dr. Bhanap P. L.

Introduction: Although dyslipedimia is a well established risk factor for coronary artery disease, its relationship to ischemic cerebrovascular disease has remained unclear, perhaps because of the heterogeneous nature of stroke. Aims and Objectives: To study the clinico-laboratory correlation of stroke due to intracranial, extracranial and combined vascular lesions. Material and Method: in the present study 104 cases of ischemic stroke were included in the study. All these patients were studied clinically and radiologically to study the nature of lesion (intracranial or extracranial vascular lesion). Neuroimaging- MRI-Brain or CT-Brain was done in each patient to see site of infarct. Routine laboratory evaluation- blood sugar, renal function tests, haemogram, lipid profile and serum vitamin B12 and homocysteine levels are calculated in all patients. Results: 49.04% of patients included in our study were having vitamin B12 deficiency. Raised serum homocysteine levels were seen in 61.54% patients. Hypertension was found in 76.92% of total patients whereas 41.35% of patients were having diabetes mellitus. 30.77% of patients with ischaemic stroke were having hypercholesterolaemia. It was observed that 33.65% patients of ischaemic stroke were having raised serum triglyceride levels and 52.88% patients were having raised LDL levels. Patients having low HDL cholesterol levels were 67.30%. Conclusion: Thus we conclude that raised homocysteine levels, hypercholesterolaemia, hypertriglyceridaemia and raised LDL levels are found to be important risk factors for ischaemic strokes due to extracranial vascular lesion. HDL appears to have protective influence on extracranial vascular lesion.