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MedPulse - International Medical Journal, ISSN 2348-2516 E-ISSN: 2348-1897
Volume 1, Issue 9, Sept 2014 pp 520-524
Research Article
Comparison of analgesic effects of equipotent doses of intrathecal morphine and buprenorphine during spinal anaesthesia with hyperbaric bupivacaine
Raju G1, Priyanka V2, Dayananda V P3
Department of Anaesthesiology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, INDIA.
Abstract
Aims and objectives: A comparative study using equipotent doses of intrathecal morphine and buprenorphine during spinal anesthesia with 0.5% hyperbaric bupivacaine. Methods: A prospective randomized hospital basedcomparative study 200 patients belonging to ASA physical status I and II scheduled for various surgeries under spinal anaesthesia were grouped into two groups of 100 each. Group B consisting of 100 patients were given 3 ml of 0.5% hyperbaric bupivacaine along with 100 µg of buprenorphine and group M consisting of 100 patients were given 3 ml of 0.5% hyperbaric bupivacaine along with 100 µg of morphine intrathecally. Onset and duration of sensory and motor block, maximum height of sensory block, time to request for rescue analgesia, haemodynamic parameters and adverse effects were studied. Results: The mean time to request for rescue analgesia was longer in group B when compared to group M. The mean time of onset of sensory and motor block was marginally less in group B when compared to group M. The total duration of the sensory and motor block was more in group B when compared to group M. There was no significant difference among the study groups in attaining maximum height of sensory block, 2 segment regression, haemodynamic parameters, RR and sedation score. The incidence of side effects is less in group B when compared to group M. Conclusion: 100µg of buprenorphine used as an adjuvant to intrathecal 0.5% hyperbaric bupivacaine provides increase in duration of analgesia with much less side effects when compared to 100 µg of morphine.
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