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MedPulse - International Medical Journal, ISSN 2348-2516 E-ISSN: 2348-1897
Volume 2, Issue 6, June 2015 pp 319-323
Research Article
Study of systolic and diastolic dysfunction in normotensive asymptomatic patients with type 2 diabetes mellitus
A Manjula1, Devika Madhu2, Chandrashekar3, Someshekar4, Chaitra5, Rashmi6
1Associate Professor, Department of Medicine, K.R. Hospital, Mysore Medical College and Research Institute,
Mysore-570 021, Karnataka, INDIA.
Abstract
The existence of diabetic cardiomyopathy has been proposed as an evidence for the presence of myocardial dysfunction in diabetic patients in the absence of ischaemia, valvular or hypertensive heart disease. Diastolic dysfunction has been described as an early sign of diabetic heart muscle disease preceding the systolic damage. To evaluate systolic and diastolic dysfunction in asymptomatic normotensive type 2 diabetes mellitus patients. A total of 50 patients with mean age of 50.12±7.75 years with male to female ratio being 1:0.85 were selected, and 50 age and sex matched controls were also included in the present study with mean SBP of 122.84±10.72 and DBP of 78.70±5.74. All the investigations were within normal limits except mean FBS of 142±9.94 and PPBS of 226±18.61. In systolic function the mean EF was 63.12 ± 6.19 and mean FS was 35.42 ± 5.03. The EF was < 50% in 3 (6%) patients, but were asymptomatic. The mean E/A ratio was 0.95±0.10 and 26 (52%) had E/A ratio of <1 as compared to 24 (48%)>1%. The mean IVRT was 87.94 ± 20.36, and mean DT of E was 180.68 ± 34.64. p-value of < 0.05 is statistically significant. LVDD is much more common than previously reported in subjects with well controlled type 2 diabetes mellitus who are free of clinically detectable heart disease. Conventional echocardiography is a simple test to detect early LVDD in type 2 diabetes mellitus patients.
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